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C1146-02 Carbonyl Reductase 1, 1-277aa, Recombinant, Human (CBR 1, CRN, CBR, hCBR1) CAS:

Specifications
References
Grade
Highly Purified
Accession Number
NP_001748
Molecular Weight
30
EU Commodity Code
30021019
Shipping Temp
Dry Ice
Storage Temp
-70°C

CBR1(Carbonyl reductase 1) is one of several monomeric NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. CBR1 is widely distributed in human tissues. CBR1 metabolizes many toxic environmental quinones and pharmacological relevant substrates such as the anticancer doxorubicin. CBR1 can also convert prostaglandin E2 to prostaglandin F2-alpha.

Recombinant protein corresponding to aa1-277 from human CBR1, expressed in E.coli (NP_001748).
Amino Acid Sequence
MSSGIHVALV TGGNKGIGLA IVRDLCRLFS GDVVLTARDV TRGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLDVLVNN AGIAFKVADP TPFHIQAEVT MKTNFFGTRD VCTELLPLIK PQGRVVNVSS IMSVRALKSC SPELQQKFRS ETITEEELVG LMNKFVEDTK KGVHQKEGWP SSAYGVTKIG VTVLSRIHAR KLSEQRKGDK ILLNACCPGW VRTDMAGPKA TKSPEEGAET PVYLALLPPD AEGPHGQFVS EKRVEQW
Enzyme Activity
Not determined. This product is recommended for use in applications that do not require a catalytically active form of the protein.
Storage and Stability
Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Source
Recombinant, E. coli
Purity
≥95% (SDS-PAGE)
Concentration
~1mg/ml
Form
Supplied as liquid in 20mM Tris-HCl, pH8.5, 10% glycerol.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Bateman RL., et al. (2008), J Biol Chem. 283(51):35756-62, 2. Plebuch M., et al. (2007). Cancer Lett. 255(1):49-56.
USBio References
No references available
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