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You are here:Home » Molecular Biology » MB-Proteins » Carbonyl Reductase 3, Recombinant, Human (CBR3 , hCBR3, Carbonyl reductase (NADPH) 3)

Carbonyl Reductase 3, Recombinant, Human (CBR3 , hCBR3, Carbonyl reductase (NADPH) 3)

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Specifications

Carbonyl reductase 3(CBR3) is one of several monomeric NADPH-dependent oxidoreductases. This protein catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. It also contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene CBR1. Some studies suggest that it mediates 9-cis-retinoic acid-induced cytostatis and is a potential prognostic marker for oral malignancy.
Catalog #C1146-03
SourceRecombinant human CBR3, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Molecular Weight33kD(297aa)
AA SequenceMGSSHHHHHH SSGLVPRGSH MSSCSRVALV TGANRGIGLA IARELCRQFS GDVVLTARDV ARGQAAVQQL QAEGLSPRFH QLDIDDLQSI RALRDFLRKE YGGLNVLVNN AAVAFKSDDP MPFDIKAEMT LKTNFFATRN MCNELLPIMK PHGRVVNISS LQCLRAFENC SEDLQERFHS
ETLTEGDLVD LMKKFVEDTK NEVHEREGWP NSPYGVSKLG VTVLSRILAR RLDEKRKADR ILVNACCPGP VKTDMDGKDS IRTVEEGAET PVYLALLPPD ATEPQGQLVH DKVVQNW
Storage and StabilityFor long-term storage, aliquot and store at -20°C/-70°C. Aliquots are stable for at least 6 months at -20°C/-70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight33kD
SourceE. coli
Purity~95% by SDS-PAGE
ConcentrationAs reported
FormSupplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 10% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCBR3, NADPH-dependent carbonyl reductase


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