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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -CARD8 (Caspase Recruitment Domain, Cardinal/TUCAN)

Anti -CARD8 (Caspase Recruitment Domain, Cardinal/TUCAN)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IC FC
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARDcontaining protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pesudo- ICE. Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-£eB activation.
Catalog #C1349-05C
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Dot Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested.
Recommended DilutionsFlow Cytometry: 0.5-2ug/ml
Western Blot: 0.2-2ug/ml
Immunocytochemistry: 2-100ug/ml
Immunoprecipitation: 100-500ug/sample
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8C55
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenPartial recombinant sequence from human CARD8
SpecificityRecognizes human CARD8.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesDACAR, DKFZp779L0366, KIAA0955, MGC57162, NDPP1


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