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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -CARD8 (TUCAN, DACAR, Caspase Recruitment Domain-containing Protein 8, Apoptotic Protein NDPP1, CARD-inhibitor of NF-kappa-B-activating Ligand, CARDINAL, Tumor Up-regulated CARD-containing Antagonist of CASP9, KIAA0955, NDPP1)

Anti -CARD8 (TUCAN, DACAR, Caspase Recruitment Domain-containing Protein 8, Apoptotic
Protein NDPP1, CARD-inhibitor of NF-kappa-B-activating Ligand, CARDINAL, Tumor
Up-regulated CARD-containing Antagonist of CASP9, KIAA0955, NDPP1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
TUCAN (Tumor Up-regulated Card-containing Antagonist of Caspase-Nine) is a CARD (Caspase-Associated Recruitment Domains) containing protein that binds and suppresses activation of pro-Caspase-9 and found to be overexpressed in some types of cancers. TUCAN binds specifically to pro-caspase-9 and interferes with its interaction with Apaf-1, thereby suppressing apoptosis signaling in the mitochondrial/cytochrome c pathway.
Catalog #C1349-05J
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
PurityPurified by Protein A affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa420 from human TUCAN.
SpecificityRecognizes human TUCAN/CARD8 at ~47kD. Species Crossreactivity: Mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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