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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -CARD9 (Caspase Recruitment Domain)

Anti -CARD9 (Caspase Recruitment Domain)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IC
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD containing protein was recently identified and designated CARD9, which interacts with the CARD activation domain of Bcl-10 (1). CARD9 associates with Bcl-10 and forms a complex within cells. CARD9 induces apoptosis and activates NF-kB. CARD9 is an upstream activator of Bcl-10 and NF-kB signaling.
Catalog #C1350
ApplicationsSuitable for use in ELISA, Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 0.5-1ug/ml detects a band at 59kD.
Immunocytochemistry: 10ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlWestern Blot:
P3113-99: PC-3 Cell Lysate Human Prostate Adenocarcinoma
MDA-MB-361 cell lysate
Immunocytochemistry:
K0001-05: K562 Cell Lysate
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa521-536, DRENTTGSDNTDTEGS, of human CARD9.
SpecificityRecognizes human CARD9 at ~59kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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