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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -CARD10 (Caspase Recruitment Domain-containing Protein 10, CARD-containing MAGUK Protein 3, Carma 3, CARMA3)

Anti -CARD10 (Caspase Recruitment Domain-containing Protein 10, CARD-containing MAGUK
Protein 3, Carma 3, CARMA3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B IC IF
Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD10. This protein belongs to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-kB. CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the IKK complex, demonstrating its importance in the regulation of NF-kB transcription factor activation.
Catalog #C1350-10E
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionImmunofluorescence: 5-10ug/ml
Western Blot: 5-10ug/ml
Immunocytochemistry: 5-10ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlEL4 cell lysate.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified
ImmunogenSynthetic peptide corresponding to human CARD10.
SpecificityRecognizes human CARD10. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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