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You are here:Home » Antibodies » Antibodies-Apoptosis, Caspase » Anti -CARD10 (Caspase Recruitment Domain-containing Protein 10, CARD-containing MAGUK Protein 3, Carma 3, CARMA3)

Anti -CARD10 (Caspase Recruitment Domain-containing Protein 10, CARD-containing MAGUK
Protein 3, Carma 3, CARMA3)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
CARMA proteins are scaffold molecules that belong to the membrane-associated guanylate kinase-like (MAGUK) and the caspase-associated recruitment domain (CARD) protein families. They play critical role in antigen receptor signaling pathways. CARMA1, CARMA2, and CARMA3 share homologous sequence and function but are found in different tissues. CARMA1 is predominantly located in lymphoid tissue. CARMA1 protein associates with lipid rafts and interacts with Bcl10, that is required for activation of TCR induced NFkB signaling pathway. Specifically, CARMA1 N-terminal CARD domain binds to Bcl10 CARD motif. It is also essential for protein- induced IL-2 and INF-g production. CARMA genes deactivation studies in mice resulted in reduced immunoglobulin levels and absence of TCR-induced NFkB activation. This suggests that CARMA mutations may lead to adaptive and innate immunity malfunction.
Catalog #C1350-10G
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Immunohistochemistry: 2.5-20ug/ml (10ug/ml-optimal)
Optimal dilutions to be determined by the researcher.
Positive ControlNIH/3T3 and Jurkat whole cell lysates at ~130kD, human tissues including heart, kidney, small and large intestine, testies, and skeletal muscle
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the inner domain of human CARMA3. Species sequence homology: mouse, rat, chimpanzee and monkey.
SpecificityRecognizes human CARMA3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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