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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -CARMA2 (Caspase Recruitment Domain-containing Protein 14, CARD-containing MAGUK Protein 2, Carma 2, CARD14)

Anti -CARMA2 (Caspase Recruitment Domain-containing Protein 14, CARD-containing MAGUK
Protein 2, Carma 2, CARD14)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
CARMA proteins are scaffold molecules that belong to the membrane-associated guanylate kinase-like (MAGUK) and the caspase-associated recruitment domain (CARD) protein families. They play critical role in antigen receptor signaling pathways. CARMA1, CARMA2, and CARMA3 share homologous sequence and function but are found in different tissues. CARMA1 is predominantly located in lymphoid tissue. CARMA1 protein associates with lipid rafts and interacts with Bcl10, that is required for activation of TCR induced NFkB signaling pathway. Specifically, CARMA1 N-terminal CARD domain binds to Bcl10 CARD motif. It is also essential for protein- induced IL-2 and INF-g production. CARMA genes deactivation studies in mice resulted in reduced immunoglobulin levels and absence of TCR-induced NFkB activation. This suggests that CARMA mutations may lead to adaptive and innate immunity malfunction.
Catalog #C1350-41A
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Immunohistochemistry: 2.5-20ug/ml (10ug/ml-optimal)
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the internal portion of human CARMA2.
SpecificityRecognizes human CARMA2. Species sequence homology: monkey and chimpanzee.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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