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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified B

Cardiotin is a high molecular weight protein complex (300kD) located in the longitudinal SR of cardiomyocytes. The cardiotin structure exists of subunits of 60kD and 100kD. Both subunits contain the same amino-terminal 14 amino acid sequence, showing high homology to human skeletal muscle a-actinin, suggesting that the tetrameric configuration of the cardiotin protein structure is a transmembrane complex with the N-terminus at the cytoplasmic side of the membrane, able to interact with actin. During cardiac contractile dysfunction, a decreased SR activity is detected. The cardiotin distribution is affected in pathological cardiomyocytes i.e. chronic ischemic myocardium.
Catalog #	C1384-25
Clone Type	Monoclonal
Isotype	IgM
Clone No	2Q2275
Host	Mouse
Source	Human
Concentration	~1mg/ml
Form	Liquid in buffer with 0.1% sodium azide.
Purity	Purified immunoglobulin.
Immunogen	300 kD cardiotin protein
Specificity	Reacts with cardiotin, a sacroplasmic/endoplasmic reticulum related protein. Reacts with the 300kD cardiotin protein complex and its 100kD and 60kD subunits by Western blot. Reacts with cardiomyocytes and epithelial cells. Species Reactivity: Human and porcine.
Important Note	This product is intended for research use only, not for use in human, therapeutic or diagnostic applications.