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You are here:Home » Antibodies » Abs to Cardiotin » Anti -Cardiotin

Anti -Cardiotin

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B
Cardiotin is a high molecular weight protein complex (300kD) located in the longitudinal SR of cardiomyocytes. The cardiotin structure exists of subunits of 60kD and 100kD. Both subunits contain the same amino-terminal 14 amino acid sequence, showing high homology to human skeletal muscle a-actinin, suggesting that the tetrameric configuration of the cardiotin protein structure is a transmembrane complex with the N-terminus at the cytoplasmic side of the membrane, able to interact with actin. During cardiac contractile dysfunction, a decreased SR activity is detected. The cardiotin distribution is affected in pathological cardiomyocytes i.e. chronic ischemic myocardium.
Catalog #C1384-25
Clone TypeMonoclonal
IsotypeIgM
Clone No2Q2275
HostMouse
SourceHuman
Concentration~1mg/ml
FormLiquid in buffer with 0.1% sodium azide.
PurityPurified immunoglobulin.
Immunogen300 kD cardiotin protein
SpecificityReacts with cardiotin, a sacroplasmic/endoplasmic reticulum related protein. Reacts with the 300kD cardiotin protein complex and its 100kD and 60kD subunits by Western blot. Reacts with cardiomyocytes and epithelial cells. Species Reactivity: Human and porcine.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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