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You are here:Home » Antibodies » Abs to Neurotrophins » Anti -Cardiotrophin 1 (CT-1)

Anti -Cardiotrophin 1 (CT-1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Cardiotrophin-1 (CT-1) is a member of the cytokine family, which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT-1 has since been shown to be a pleiotropic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Human CT-1 encodes a 201 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. CT-1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower level of CT-1 expression is also seen in testis and brain. CT-1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor b subunit. A third a receptor subunit has recently been implicated in the receptor complex.
Catalog #C1385-13
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 0.05-0.2ug/ml
Western Blot: 0.1-1.0ug/ml
Optimal dilutions to be determined by the researcher.
Hybridoma Spleen cells are fused with SP2/0-Ag14 mouse myeloma cells.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute by adding sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20ºC. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No9E1
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder from PBS, pH 7.4, 0.02% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenCT-1 full length recombinant protein with His tag.
SpecificityRecognizes human CT-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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