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Abs to Apoptosis, Caspase
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Anti -CARMA1 (Caspase Recruitment Domain-containing Protein 11, CARD-containing MAGUK Protein 1, Carma 1, CARD11)
Anti -CARMA1 (Caspase Recruitment Domain-containing Protein 11, CARD-containing MAGUK
Protein 1, Carma 1, CARD11)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
B IH |
|
| CARMA1 is a 1154aa protein playing a major role in the activation of NF-kappa-B through BCL10 and IKK. It contains a caspase-associated recruitment domain (CARD) and is thus included in the CARD protein family, a guanylate kinase-like domain and a PDZ (DHR) domain. The domain structure is similar to that of CARD14 protein and belongs to a class of proteins known as the membrane-associated guanylate kinase (MAGUK) family acting as molecular scaffolds. Binding of CARD11 and BCL10, a positive regulator of cell apoptosis and NF-kappaB activation, to each other occurs by CARD-CARD interaction and it stimulates the phosphorylation of BCL10. CARMA1 is detected in adult peripheral blood leukocytes, thymus, spleen and liver and in some cell lines except in HeLa S3, Molt-4, A549 and G431 cells. | | | Catalog # | C1385-26F | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 1-3ug/ml | | Western Blot: 1-3ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Jurkat Cell line Lysates | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to CQRKTIWVDEDQL, from the C-terminus of the protein sequence according to NP_115791. | | Specificity | Recognizes CARMA1. Species sequence homology: mouse and human. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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