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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, beta, phosphorylated (Ser33, Ser37)

Anti -Catenin, beta, phosphorylated (Ser33, Ser37)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
B-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (1). The role of B-catenin in these processes is thought to be regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3B (GSK3B) (2). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of B-catenin. Mutations in components of this phosphorylation regulated process that prevent B-catenin hyperphosphorylation by GSK3B are strongly associated with cancers (4, 3, 2).
Catalog #C2069-40C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenPhosphopeptide corresponding to amino acid residues surrounding the phospho-Ser33,37 of human B-catenin.
Cellular LocalizationCytoplasmic or bound to CDH1. Translocates to the nucleus.
SpecificityRecongizes human beta-Cateninin. Specific for the ~83k B-catenin phosphorylated at Ser33,37 in Western Blots of human embryonic kidney cells. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCadherin associated protein, CATNB, CTNNB, CTNNB1


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