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You are here:Home » Antibodies » Antibodies-Catenin » Anti -Catenin, beta, phosphorylated (Ser33, Ser37)

Anti -Catenin, beta, phosphorylated (Ser33, Ser37)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
B-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (1). The role of B-catenin in these processes is thought to be regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3B (GSK3B) (2). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of B-catenin. Mutations in components of this phosphorylation regulated process that prevent B-catenin hyperphosphorylation by GSK3B are strongly associated with cancers (4, 3, 2).
Catalog #C2069-40C
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to amino acid residues surrounding Ser33,37 of human B-catenin, conjugated to KLH.
Species sequence homologyMouse, rat, xenopus
SpecificityRecongizes human beta-Cateninin. Specific for the ~83kD B-catenin phosphorylated at Ser33,37.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCadherin associated protein, CATNB, CTNNB, CTNNB1


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