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You are here:Home » Antibodies » Abs to Catenin » Anti -CTNNA1 (Catenin alpha-1, Catenin alpha1, Alpha E-catenin, Cadherin-associated Protein, Renal Carcinoma Antigen NY-REN-13)

Anti -CTNNA1 (Catenin alpha-1, Catenin alpha1, Alpha E-catenin, Cadherin-associated
Protein, Renal Carcinoma Antigen NY-REN-13)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Three catenin proteins, a, b and y, bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. The catenin/cadherin complexes play an important role mediating cellular adhesion. Not only associated with E-cadherin, a-catenin was also shown to associate with other members of the cadherin family, such as Ncadherin and P-cadherin. b-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. b-catenin has also been found in complexes with the tumor suppressor protein APC. y-catenin, also known as plakoglobin, is a protein that binds with a-catenin and N-cadherin. It has been shown that the transmembrane phosphatase PTP associates with catenin/cadherin complexes and may regulate complex signaling.
Catalog #C2069-40K1
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot:1:500-1:1,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic non-phosphopeptide corresponding to human a-catenin around the phosphorylation site of serine 641 (D-D-SP-D-F).
SpecificityRecognizes human Catenin alpha1. Species Cross-Reactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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