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Abs to Catenin
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Anti -CTNNA1, NT (Catenin alpha-1, Catenin alpha1, Alpha E-catenin, Cadherin-associated Protein, Renal Carcinoma Antigen NY-REN-13)
Anti -CTNNA1, NT (Catenin alpha-1, Catenin alpha1, Alpha E-catenin, Cadherin-associated
Protein, Renal Carcinoma Antigen NY-REN-13)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IH |
|
| The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and are required for cadherin function. a-Catenin is a 102kD protein that is associated with the cadherin indirectly through its interaction with b-catenin and g-catenin. b-Catenin and its homolog plakoglobin associate directly with the cadherin. Thus, the cell-cell adherens junction is a structure composed of the transmembrane cadherin, which is associated directly with either b-catenin or plakoglobin, which in turn assoctiates directly with a-catenin. a-Catenin then mediates the interaction between the cadherin-catenin complex and the actin cytoskeleton (5,6). a-Catenin has been characterized as a tumor suppressor, suggesting that it may have a regulatory function in regulation to its structural role. | | | Catalog # | C2069-40N | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 2.5-5ug/ml | | Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to human CTNNA1 at N-terminal (KLH). | | Specificity | Recognizes human CTNNA1. Species sequence homology: Xenopus and mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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