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You are here:Home » Antibodies » Abs to Catenin » Anti -CTNNA1, NT (Catenin alpha-1, Catenin alpha1, Alpha E-catenin, Cadherin-associated Protein, Renal Carcinoma Antigen NY-REN-13)

Anti -CTNNA1, NT (Catenin alpha-1, Catenin alpha1, Alpha E-catenin, Cadherin-associated
Protein, Renal Carcinoma Antigen NY-REN-13)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and are required for cadherin function. a-Catenin is a 102kD protein that is associated with the cadherin indirectly through its interaction with b-catenin and g-catenin. b-Catenin and its homolog plakoglobin associate directly with the cadherin. Thus, the cell-cell adherens junction is a structure composed of the transmembrane cadherin, which is associated directly with either b-catenin or plakoglobin, which in turn assoctiates directly with a-catenin. a-Catenin then mediates the interaction between the cadherin-catenin complex and the actin cytoskeleton (5,6). a-Catenin has been characterized as a tumor suppressor, suggesting that it may have a regulatory function in regulation to its structural role.
Catalog #C2069-40N
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 2.5-5ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human CTNNA1 at N-terminal (KLH).
SpecificityRecognizes human CTNNA1. Species sequence homology: Xenopus and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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