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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, alpha (Catenin alpha-1, CTNNA1, Alpha E-catenin, CAP102, Cadherin-associated Protein, FLJ36832, FLJ52416, Renal Carcinoma Antigen NY-REN-13)

Anti -Catenin, alpha (Catenin alpha-1, CTNNA1, Alpha E-catenin, CAP102,
Cadherin-associated Protein, FLJ36832, FLJ52416, Renal Carcinoma Antigen NY-REN-13)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IH
E-cadherin is a transmembrane glycoprotein responsible for physical connection of epithelial cells through Ca(2+)-binding regions in its extracellular domain. E-cadherin-mediated cell-cell adhesion is effected by 3 cytoplasmic proteins known as catenins alpha, beta, and gamma. These catenins are thought to work as connectors that anchor the E-cadherin to the cytoskeletal actin bundle through the cadherin cytoplasmic domain. Alpha-catenin, a cadherin-associated protein, links cadherin/beta-catenin and cadherin/plakoglobin complexes to the actin cytoskeleton.Thus it is required for the function of cadherins, cell adhesion molecules.The gene encodes 906 amino acids and is mapped to 5q31. Pathological role of alpha-catenin has been observed in human myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). It is expressed ubiquitously in normal tissues. Alternatively spliced transcript variants encoding two isoforms have been identified.
Catalog #C2069-40P
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:50-1:100
Western Blot: 1:100-750
Optimal dilutions to be determined by the researcher.
Positive ControlHuman lung cell line
Cellular Localization
Cytoplasmic and cell membrane
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 0.05% sodium azide.
PuritySerum
ImmunogenSynthetic peptide derived from the C-terminus of human Catenin, alpha protein.
SpecificityRecognizes human Alpha-Catenin. Species Crossreactivity: mouse and xenopus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCatenin (Cadherin-associated Protein), alpha 1, 102kDa


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