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Anti -Catenin, alpha T (alpha T-Catenin, a-T-Catenin, Catenin (Cadherin Associated Protein) alpha 3, Catenin alpha-3, Ctnna3, VR22)
Anti -Catenin, alpha T (alpha T-Catenin, a-T-Catenin, Catenin (Cadherin Associated
Protein) alpha 3, Catenin alpha-3, Ctnna3, VR22)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Alpha-catenins stabilize the cell-cell contacts by functioning as a molecular switch that regulates actin dynamics at the site of the adherens junction (1). Alpha-T Catenin is involved in the formation of stretch-resistant cell-cell adhesion complexes (2). Alpha-T catenin is expressed predominantly in cardiomyocytes, where it colocalizes with alpha-E catenin at the intercalated discs (1). Moreover, alpha-T Catenin is also expressed in the brain and inhibits Wnt signaling, so it is implicated in Alzheimer’s disease (3). | | | Catalog # | C2069-41G | | pplications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:1,000 | | Western Blot: 1:100-1:500 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide selected from the Center region of human VR22 (KLH). | | Specificity | Recognizes human VR22. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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