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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin alpha1 (CTNNA1, Catenin (Cadherin-associated Protein), alpha 1, 102kDa, HGNC:2509, CAP102, FLJ36832, alpha 1 (102kD), alpha-E-Catenin, alpha-Catenin, alphaE-Catenin)

Anti -Catenin alpha1 (CTNNA1, Catenin (Cadherin-associated Protein), alpha 1, 102kDa,
HGNC:2509, CAP102, FLJ36832, alpha 1 (102kD), alpha-E-Catenin, alpha-Catenin,
alphaE-Catenin)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse E B IP IC
The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and are required for cadherin function. a-catenin is a 102kD protein that is associated with the cadherin indirectly through its interaction with b-catenin and g-catenin. b-Catenin and its homolog plakoglobin associate directly with the cadherin. Thus, the cell-cell adherens junction is a structure composed of the transmembrane cadherin, which is associated directly with either b-catenin or plakoglobin, which in turn assoctiates directly with a-catenin. a-Catenin then mediates the interaction between the cadherin-catenin complex and the actin cytoskeleton. a-Catenin has been characterized as a tumor suppressor, suggesting that it may have a regulatory function in regulation to its structural role.
Catalog #C2069-44H
Applications
Suitable for use in ELISA, Immunocytochemistry, Immunoprecipitation, and Western Blot. Other applications have not been tested.
Recommended DilutionsWestern Blot: 0.5ug/ml for HRP/ECL detection. Recommended Blocking buffer: Casein/Tween 20 based blocking and blot incubation buffer.
Immunoprecipitation: 1-10ug per 10e6 vanadate treated A431 cells
Immunocytochemistry: 0.1-1ug/ml; alpha catenin may tolerate formaldehyde fixation
ELISA: 0.05ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlA0001-50B: A431 Cell Lysate, untreated
Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No6D202
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.09% azide, PEG and sucrose.
PurityPurified by thiophilic adsorption and size exclusion chromatography.
ImmunogenRecombinant protein corresponding to human alpha-catenin.
SpecificityRecognizes human alpha-catenin. Detects a band of ~102kD. Species Crossreactivity: mouse, rat, and canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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