Anti -Catenin, beta (Beta Catenin, Cadherin-associated Protein, Catenin beta 1, CATNB,
CTNNB, CTNNB1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B FC |
|
| Beta-catenin is a key regulatory protein involved in cell adhesion and signal transduction through the Wnt pathway, and plays important roles in development, cellular proliferation, and differentiation (1). b-catenin is phosphorylated at four serine and threonine residues at the | | | N-terminus (2). Ser 45 is phosphorylated by CK1, and is thought to be a priming site for the phosphorylation by glycogen synthase kinase-3 (GSK-3) of the remaining three residues, Thr 41, Ser 37, and Ser 33 (2). Wnt signaling antagonizes the action of GSK-3, which in subsequent | | | phosphorylation steps, leads to its degradation (3). Mutations in the b-catenin gene, CTNNB1, have been implicated in its accumulation and various forms of carcinomas (4). | | | Catalog # | C2069-49B | | Applications | Suitable for use in Flow Cytometry and Western Blot. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:200 | | Western Blot: 1:500 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9H315 | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | | Purity | Supernatant | | Immunogen | A synthetic peptide corresponding to residues on the C-terminus of human beta catenin. | | Specificity | Recognizes human beta-catenin. Species Crossreactivity: Mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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