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Specifications

Clone Host Grade Applications Monoclonal Mouse Ascites B IC IF Gel

The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues bind to the conserved cytoplasmic tail domain of the
cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.
Catalog #	C2069-49M
Applications	Suitable for use in Immunofluorescence, Western Blot, Immunocytochemistry and Gel Super Shift assays. Other applications not tested.
Recommended Dilution	Immunofluorescence: 1:1000
	Western Blot: 1:1000
	Optimal dilutions to be determined by the researcher.
Positive Control	Cultured MDBK cells or cell extract.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	8J537
Host	Mouse
Source	Chicken
Concentration	Not determined
Form	Supplied as a liquid in 0.1% sodium azide.
Purity	Ascites
Immunogen	Recombinant full length chicken beta catenin. Cellular Localization: Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation).
Specificity	Recognizes chicken beta-catenin (Mr
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	Cadherin associated protein, CATNB, CTNNB, CTNNB1