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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, beta, phosphorylated (Ser33) (Beta Catenin, Cadherin-associated Protein, Catenin beta 1, CATNB, CTNNB, CTNNB1)

Anti -Catenin, beta, phosphorylated (Ser33) (Beta Catenin, Cadherin-associated Protein,
Catenin beta 1, CATNB, CTNNB, CTNNB1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
b-Catenin, an adherens junction protein was originally identified as a component of cell-cell adhesion structures. It interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Recent results show that it also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis. The protein is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. Pathological role of b-catenin has been identified in pilomatrixoma, medulloblastoma and tumor development. Human b-Catenin gene is localized in the chromosomal region 3p21.
Catalog #C2069-49S
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Immunohistochemistry (paraffin): 1:50-1:100
Optimal dilutions to be determined by the researcher.
Positive ControlSW 626 cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human b-Catenin around the phosphorylation site of serine 33 (L-D-SP-G-
SpecificityRecognizes human b-Catenin, phosphorylated at Ser33. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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