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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, beta

Anti -Catenin, beta

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IF
Beta-catenin belongs together with alpha- and gamma-catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Beta-catenin is highly homologous to gamma-catenin (plakoglobin) although its function differs from that of plakoglobin. Whereas plakoglobin has been found to suppress tumorigenicity, beta-catenin potentiates hyperproliferation and tumor formation. In the nucleus beta-catenin it complexes with transcription factors and thus regulates the expression of specific genes. By its dual role, i.e. a structural role in cell-cell junctions and a regulatory role in the nucleus, beta-catenin can transduce changes in cell adhesion and junction formation to control transmembrane signalling and gene expression.
Catalog #C2069-50E
ApplicationsCan be used for Western Blot, Immunoprecipitation and Immunofluorescence with cells fixed in paraformaldehyde.
Recommended DilutionWestern Blot: 1:10
Immunofluorescence: 1:10
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20°C or colder. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6A490
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, containing 0.02% sodium azide and 0.1% BSA.
PurityPurified IgG
SpecificityRecognizes human beta-Catenin.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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