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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, beta (Catenin (cadherin-associated protein), beta 1, beta-catenin, Beta-catenin, Catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, OK/SW-cl.35, PRO2286)

Anti -Catenin, beta (Catenin (cadherin-associated protein), beta 1, beta-catenin,
Beta-catenin, Catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, OK/SW-cl.35,
PRO2286)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as alpha-catenin and beta-catenin. alpha-catenin can bind to beta-catenin and can also bind actin. beta-catenin binds the cytoplasmic domain of some cadherins. When beta-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in beta-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When beta-catenin is not associated with cadherins and alpha-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that beta-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy, HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.
Catalog #C2069-50J
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHEK293 lysat
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in 0.1M Tris-Glycine, pH7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human beta catenin (KLH). Cellular Localization: Cytoplasm. Nucleus. Cytoplasm cytoskeleton.
SpecificityRecognizes human beta catenin regardless of phosphorylation state. Species sequence homology: mouse, rat, xenopus, and chicken.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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