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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, beta, phosphorylated (Thr41/Thr45) (catenin (cadherin-associated protein), beta 1, 88kD, beta-catenin, Beta-catenin, Catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, OK/SW-cl.35, PRO2286)

Anti -Catenin, beta, phosphorylated (Thr41/Thr45) (catenin (cadherin-associated protein),
beta 1, 88kD, beta-catenin, Beta-catenin, Catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606,
FLJ37923, OK/SW-cl.35, PRO2286)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP
Beta-Catenin links Cadherin cell adhesion proteins to the cytoskeleton and has recently been implicated in the Wnt/Wingless signaling pathway and in the progression of neoplasia. Beta-Catenin associates with the tumor suppressor Adenomatous Polypopsis Coli (APC) and functions as a co-activator of the TCF transcription factor family. It is regulated by Glycogen Synthase Kinase (GSK) 3b, which phosphorylates and targets beta-Catenin for ubiquitin-mediated proteolysis. Stabilization of beta-Catenin, either by Wnt-mediated inhibition of GSK3b or by mutation (as found in numerous colorectal tumors and melanoma cell lines), results in activation of TCF responsive genes which are thought to play key roles in development and cancer progression. Delta-Catenin (NPRAP/Neurojungin), a member of the p120 Catenin subfamily, is a structural protein involved in neuronal development. It interacts with Actin, Cortactin and Src Kinases to promote neurite elongation or branching, depending upon its phosphorylation state.
Catalog #C2069-50K
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:10,000-1:20,000
Immunoprecipitation: 1:20
Optimal dilutions to be determined by the researcher.
Positive Control293T cell lysates
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H205
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
PuritySupernatant
ImmunogenPhospho specific peptide corresponding to residues surrounding threonine 41 and 45 of human beta-catenin. Cellular Localization: Cytoplasm. Nucleus. Cytoplasm cytoskeleton.
SpecificityRecognizes human beta-catenin phosphorylated on threonine 41 and/or threonine 45 near the N-terminus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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