Anti -Catenin, beta, NT (Catenin (cadherin associated protein), beta 1, 88kD,
beta-catenin, Beta-catenin, Catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923,
OK/SW-cl.35, PRO2286)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IP IH IC |
|
| Beta-Catenin links Cadherin cell adhesion proteins to the cytoskeleton and has recently been implicated in the Wnt/Wingless signaling pathway and in the progression of neoplasia. beta-Catenin associates with the tumor suppressor Adenomatous Polypopsis Coli (APC) and functions as a co-activator of the TCF transcription factor family. It is regulated by Glycogen Synthase Kinase (GSK) 3b, which phosphorylates and targets beta-Catenin for ubiquitin-mediated proteolysis. Stabilization of beta-Catenin, either by Wnt-mediated inhibition of GSK3b or by mutation (as found in numerous colorectal tumors and melanoma cell lines), results in activation of TCF responsive genes which are thought to play key roles in development and cancer progression. Delta-Catenin (NPRAP/Neurojungin), a member of the p120 Catenin subfamily, is a structural protein involved in neuronal development. It interacts with Actin, Cortactin and Src Kinases to promote neurite elongation or branching, depending upon its phosphorylation state. | | | Catalog # | C2069-50L | | Applications | Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:5000-1:10000 | | Immunohistochemistry (paraffin): 1:500 | | Immunocytochemistry: 1:250 | | Optimal dilutions to be determined by the researcher. | | Positive Control | A431 cell lysates | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9H206 | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in 50mMTris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA. | | Purity | Supernatant | | Immunogen | Synthetic peptide corresponding to residues near the N-terminus of human beta-catenin. | | Specificity | Recognizes human beta-catenin at and around the N-terminus. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Catenin, beta, NT (Catenin (cadherin associated protein), beta 1, 88kD, beta-catenin, Beta-catenin, Catenin beta-1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, OK/SW-cl.35, PRO2286) |
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