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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, beta, phosphorylated (Ser45)

Anti -Catenin, beta, phosphorylated (Ser45)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
b-catenin (92kD) is a multifunctional protein involved in cell-cell adhesion, intracellular
signaling and gene transcription. b-catenin plays a key role in the Wnt pathway which mediates numerous developmental processes. Deregulation of the Wnt pathway results in the accumulation of b-catenin in the nucleus. Stabilizing mutations of several serine/threonine residues (more frequently of serine 45) have been found in multiple tumors. Phosphorylation of b-catenin on serine 45 by casein kinase I (CKI) primes its subsequent phosphorylation of residues 33, 37 and 41 by glycogen synthase-3b (GSK-3b) and results in its degradation.
Catalog #C2069-51A
ApplicationsSuitable for use in ELISA and Western Blotting. Other applications not tested.
Recommended DilutionWestern Blotting: 1:1000-1:2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide derived from a region of human b-catenin contains serine 45. Species sequence homology: mouse, rat and
frog.
SpecificityRecognizes human b-catenin when phosphorylated at Ser45. Species sequence homology: mouse, rat and frog b-catenin (100%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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