Anti -Catenin, beta (Beta-catenin, Catenin beta-1, CTNNB1, CTNNB, DKFZp686D02253,
FLJ25606, FLJ37923, OK/SW-cl.35, PRO2286)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
IH |
|
| Beta-Catenin, an adherens junction protein, originally identified as a component of cell-cell adhesion structures, interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Recent results show that it also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis. It is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. Pathological role of beta-catenin has been identified in pilomatrixoma, medulloblastoma and tumor development. Alternatively spliced transcript variants encoding two isoforms have been identified. | | | Catalog # | C2069-52K | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 1:100-1:200 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Breast carcinoma | | Cellular Localization | | | Cytoplasmic and cell membrane | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 0.05% sodium azide. | | Purity | Serum | | Immunogen | Synthetic peptide derived from the C-terminus of human b-catenin protein. | | Specificity | Recognizes human b-Catenin. Species Crossreactivity: chicken, mouse, rat and xenopus. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Catenin (Cadherin-associated Protein), beta 1, 88kDa |
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