Anti -Catenin, beta, phosphorylated (Ser33, Ser37) (Beta-catenin, Catenin beta-1, CTNNB1,
CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, OK/SW-cl.35, PRO2286)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
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| B-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (Ding and Dale, 2002; Polakis, 2000). The role of ?-catenin in these processes is thought regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3? (GSK3?) (Liu et al., 2002). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of ?-catenin. Mutations in components of this phosphorylation regulated process that prevent ?-catenin hyperphosphorylation by GSK3? are strongly associated with cancers (Wang et al., 2003; Polakis, 2000; Liu et al., 2002). | | | Catalog # | C2069-52L | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human embryonic kidney cell (HEK) lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug per ml BSA, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Phosphopeptide corresponding to amino acid residues surrounding the phosphorylated (Ser33,37) of human b-catenin. | | Specificity | Recognizes human b-Catenin, phosphorylated at (Ser33, Ser37). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Catenin (Cadherin-associated Protein), beta 1, 88kDa |
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Download Specifications for Anti -Catenin, beta, phosphorylated (Ser33, Ser37) (Beta-catenin, Catenin beta-1, CTNNB1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, OK/SW-cl.35, PRO2286) |
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