Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, beta, phosphorylated (Ser33, Ser37) (Beta-catenin, Catenin beta-1, CTNNB1, CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, OK/SW-cl.35, PRO2286)

Anti -Catenin, beta, phosphorylated (Ser33, Ser37) (Beta-catenin, Catenin beta-1, CTNNB1,
CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, OK/SW-cl.35, PRO2286)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
B-Catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (Ding and Dale, 2002; Polakis, 2000). The role of ?-catenin in these processes is thought regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3? (GSK3?) (Liu et al., 2002). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of ?-catenin. Mutations in components of this phosphorylation regulated process that prevent ?-catenin hyperphosphorylation by GSK3? are strongly associated with cancers (Wang et al., 2003; Polakis, 2000; Liu et al., 2002).
Catalog #C2069-52L
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlHuman embryonic kidney cell (HEK) lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid 10mM HEPES, pH 7.5, 150mM sodium chloride, 100ug per ml BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenPhosphopeptide corresponding to amino acid residues surrounding the phosphorylated (Ser33,37) of human b-catenin.
SpecificityRecognizes human b-Catenin, phosphorylated at (Ser33, Ser37).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCatenin (Cadherin-associated Protein), beta 1, 88kDa


External Links