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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, beta 1,2, Phosphorylated (Ser674) (Beta-catenin 2, ctnnb2, zgc:65770)

Anti -Catenin, beta 1,2, Phosphorylated (Ser674) (Beta-catenin 2, ctnnb2, zgc:65770)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Catenin-beta plays a central role in cell adhesion, bridging between cadherins and actin cytoskeleton. These activities are regulated through its differential interaction with several molecular partners, including cell- cell adherens junctions molecules, components of its degradation complex, and transcription factors. Catenin-beta is composed of three domains: a central armadillo repeat domain and two N- and C-terminal tails. Catenin-beta can be phosphorylated by serine-threonine kinase, such as GSK-3. The phosphorylated catenin-beta affects the protein association of catenin-beta to E-cadherin and alpha-cateinin that occurs in the cell. This process can be reversed by dephosphorylation of catenin-beta.
Catalog #C2069-53C
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Control Peptide C2069-53C1
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceZebrafish
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to the C-terminal region of zebrafish catenin-beta 2, at the phosphorylated site of Ser674 (KRL(pS)VELT).
SpecificityRecognizes zebrafish Catenin-beta 1, 2 when Phosphorylated at Ser674.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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