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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, delta

Anti -Catenin, delta


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and are required for cadherin function (2). a-catenin is a 102kD protein that is associated with the cadherin indirectly through its interaction with b-catenin and g-catenin (3). b-Catenin and its homolog plakoglobin associate directly with the cadherin (4). Thus, the cell-cell adherens junction is a structure composed of the transmembrane cadherin, which is associated directly with either b-catenin or plakoglobin, which in turn assoctiates directly with a-catenin. a- catenin then mediates the interaction between the cadherin-catenin complex and the actin cytoskeleton (5,6). a-catenin has been characterized as a tumor suppressor, suggesting that it may have a regulatory function in regulation to its structural role (7).
Catalog #C2069-54
Immunoblot Analysis 0.52ug/ml detects delta Catenin in rat brain microsomes. Rat brain microsomes were resolved by electrophoresis, transferred to nitrocellulose and probed with anti-delta-Catenin (0.5ug/ml). Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
Clone TypePolyclonal
Form100ug of protein A puri ed rabbit IgG in 100ul of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%. Liquid at-20°C.
PurityPurified by Protein A affinity chromatography.
ImmunogenGST fusion protein corresponding to residues 1461 of mouse delta Catenin.
SpecificityRecognizes delta Catenin, Mr 133kD. Species Crossreactivity: Rat and murine.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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