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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, delta 1 (CTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)

Anti -Catenin, delta 1 (CTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated
Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant E B IP IC IF
Catenins are proteins associated with complexes that contain cadherin cell adhesion molecules. Delta-1-catenin is a member of the p120 Catenin subfamily and is a structural protein involved in neuronal development. It interacts with Actin, Cortactin and Src Kinases to promote neurite elongation or branching, depending upon its phosphorylation state. Like beta-catenin and gamma-catenin, delta-catenins appear to interact with presenilins. These catenin-presenilin interactions can impact cadherin function and regulation of cell-to-cell adhesion. While beta-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-kB transcription factor.
Catalog #C2069-54K
ApplicationsSuitable for use in ELISA, Western Blot, Immunoprecipitation, Immunofluorescence and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:10,000 using whole cell extract of cultured chicken fibroblasts. Detects a band at ~120kD and an possible additional weak doublet of ~200kD.
Immunofluorescence: 1:100 using cultured Madin Darby canine kidney (MDCK) epithelial cells.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No8J1255
HostMouse
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid, 15mM sodium azide.
PuritySupernatant
ImmunogenRecombinant corresponding to the N-terminal fragment of mouse delta 1 Catenin. Cellular Localization: Cytoplasmic.
SpecificityRecognizes mouse delta 1 Catenin. Specifically reacts with the N-terminal region. Reacts with isoforms 1 and 2 but does not react with isoforms 3 or 4. Species Crossreactivity: rat, bovine, chicken, canine, human .
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384


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