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You are here:Home » Antibodies » Abs to Catenin » Anti -Catenin, delta 1, phosphorylated (Tyr228) (CTNND1, Cadherin-Associated Protein delta 1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)

Anti -Catenin, delta 1, phosphorylated (Tyr228) (CTNND1, Cadherin-Associated Protein delta
1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Catenin -1 (p120 catenin) has an amino- terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten, linked 42 amino-acid repeats. The carboxy-terminal tail has no known function (1). Catenin -1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin -1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin -1, which modulates RhoA, Rac and cdc42 proteins (1). Analogous to -catenin, catenin -1 translocates to the nucleus although its role at this location is unclear. Many studies show that catenin -1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin -1 may func- tion as a tumor suppressor (4).
Catalog #C2069-54M
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
FormSupplied as a liquid in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100ug/ml BSA and 50% glycerol.
PurityPurified by peptide affinity chromatography.
ImmunogenSynthetic phosphopeptides (KLH-coupled) corresponding to residues surrounding Tyr228 of human/mouse catenin -1.
SpecificityDetects endogenous levels of catenin -1 protein only when phosphorylated at Tyr228. The antibody might cross react with another overexpressed phospho-tyrosine protein.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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