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You are here:Home » Antibodies » Abs to Catenin » Anti -CTNND1 (Catenin delta-1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)

Anti -CTNND1 (Catenin delta-1, Cadherin-associated Src Substrate, CAS, p120 Catenin,
p120(ctn), p120(cas), KIAA0384)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
P120 catenin (p120) is a component of adherent junctions and has been implicated in regulating cadherin-based cell adhesion as well as the activity of Rho small GTPases. P120 promotes lateral clustering of cadherins and regulates cadherin stability and turnover at the cell membrane. P120 also promote cell surface trafficking of cadherins through its ability to complex with kinesin and move vesicles along microtubules. p120 is identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y258, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src. These phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation.
Catalog #C2069-54S
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the tyrosine-phosphorylated site of 228 of human P120 Catenin (SDNYGSL).
SpecificityRecognizes human Catenin, p120.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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