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Specifications

Clone Host Grade Applications Polyclonal Goat Affinity Purified E B

Plakoglobin is a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
Catalog #	C2069-55A
Cellular Localization	Cytoplasmic in a soluble and membrane-associated form.
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Goat
Concentration	~0.5mg/ml
Form	Supplied as a liquid in TBS, pH 7.2, 0.5% BSA.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide: GLRPPYPTADHMLA, representing the C-Terminus of the human protein (residues 730-743), according to NP_002221, NP_068831.
Specificity	Species Crossreactivity: Crossreacts with Human. Expected to crossreact with Mouse (100% identity with immunogen), Rat (92% identity with immunogen), bovine (92% identity with immunogen) and porcine (92% identity with immunogen) due to sequence homology.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names	Desmoplakin III, DP3, DPIII, Gamma catenin, Junction plakoglobin, PDGB, PKGB