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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 1, CT (Caspase 1 Apoptosis-related Cysteine Peptidase, Caspase 1 Apoptosis-related Cysteine Protease, Caspase-1, CASP 1, CASP1, CASP-1, Interleukin 1 beta Convertase, IL1B Convertase, IL-1BC, IL1BC, Interleukin 1 beta Converting Enzyme, Interleuki

Anti -Caspase 1, CT (Caspase 1 Apoptosis-related Cysteine Peptidase, Caspase 1
Apoptosis-related Cysteine Protease, Caspase-1, CASP 1, CASP1, CASP-1, Interleukin 1 beta
Convertase, IL1B Convertase, IL-1BC, IL1BC, Interleukin 1 beta Converting Enzyme,
Interleuki

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B IH
Caspase-1 is an intracellular cysteine protease, identified as a mammalian homologue to C. elegans cell death gene (ced-3). Caspase-1 has been classified as an inflammatory, rather than apoptotic caspase, due to its essential role in the cleavage of the inactive precursors of the cytokines IL-1beta and IL-18, into their mature activated and secretable forms. This regulation of pro-inflammatory cytokines by Caspase-1 has made inhibitors of Caspase-1 a possible target for use as therapeutic drugs for the treatment of inflammatory diseases.
Catalog #C2086-66D
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml; Detects a cleaved subunit band of ~21kD in human heart cell lysates (predicted precursor MW 45.2kD).
Immunohistochemistry (Paraffin): 2ug/ml; Does not require protein digestion pre-treatment of paraffin embedded sections e.g. trypsin or pronase prior to staining.
Optimal dilutions to be determined by the researcher.
IHC Positive ControlHuman heart tissue.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified
Immunogen16 amino acid peptide located near human Caspase-1 carboxy terminus.
SpecificityRecognizes an epitope within the C-terminal region (CT) of human Caspase-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=3.4.22.36, Interleukin 1 beta Convertase Precursor


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