Anti -Caspase 1, CT (Caspase 1 Apoptosis-related Cysteine Peptidase, Caspase 1
Apoptosis-related Cysteine Protease, Caspase-1, CASP 1, CASP1, CASP-1, Interleukin 1 beta
Convertase, IL1B Convertase, IL-1BC, IL1BC, Interleukin 1 beta Converting Enzyme,
Interleuki
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
B IH |
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| Caspase-1 is an intracellular cysteine protease, identified as a mammalian homologue to C. elegans cell death gene (ced-3). Caspase-1 has been classified as an inflammatory, rather than apoptotic caspase, due to its essential role in the cleavage of the inactive precursors of the cytokines IL-1beta and IL-18, into their mature activated and secretable forms. This regulation of pro-inflammatory cytokines by Caspase-1 has made inhibitors of Caspase-1 a possible target for use as therapeutic drugs for the treatment of inflammatory diseases. | | | Catalog # | C2086-66D | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-1ug/ml; Detects a cleaved subunit band of ~21kD in human heart cell lysates (predicted precursor MW 45.2kD). | | Immunohistochemistry (Paraffin): 2ug/ml; Does not require protein digestion pre-treatment of paraffin embedded sections e.g. trypsin or pronase prior to staining. | | Optimal dilutions to be determined by the researcher. | | IHC Positive Control | Human heart tissue. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified | | Immunogen | 16 amino acid peptide located near human Caspase-1 carboxy terminus. | | Specificity | Recognizes an epitope within the C-terminal region (CT) of human Caspase-1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | EC=3.4.22.36, Interleukin 1 beta Convertase Precursor |
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Download Specifications for Anti -Caspase 1, CT (Caspase 1 Apoptosis-related Cysteine Peptidase, Caspase 1 Apoptosis-related Cysteine Protease, Caspase-1, CASP 1, CASP1, CASP-1, Interleukin 1 beta Convertase, IL1B Convertase, IL-1BC, IL1BC, Interleukin 1 beta Converting Enzyme, Interleuki |
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