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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -CASP1 (Caspase-1, CASP-1, Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE, IL-1 beta-converting Enzyme, p45, IL1BC, IL1BCE)

Anti -CASP1 (Caspase-1, CASP-1, Interleukin-1 beta Convertase, IL-1BC, Interleukin-1
beta-converting Enzyme, ICE, IL-1 beta-converting Enzyme, p45, IL1BC, IL1BCE)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified B IH
Caspase-1 plays a vital role in cleaving the inactive procytokine pro-IL-1 beta to generate the active 17kD mature form of IL-1beta, a key mediator of inflammation. Active caspase-1 (ICE) is derived a single proenzyme of 45kD. An active ICE comprises two subunits of P20 and two subunits of P10 after removal a large amino-terminal pro-domain and a small linker peptide. Caspase-1 is reported to be involved in CD95-mediated apoptosis. Four alternatively spliced variants of caspase-1 have been reported, with mw ranging from 30-48kD.
Catalog #C2086-66G1
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
HostRat
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenBacterial fusion protein (p20)
SpecificityRecognizes human Caspase-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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