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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -CASP1 (Caspase-1, CASP-1, Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-Converting Enzyme, IL-1 beta-converting Enzyme, ICE, p45, Caspase-1 Subunit p20, Caspase-1 Subunit p10, IL1BCE, IL1BC, CASP1)

Anti -CASP1 (Caspase-1, CASP-1, Interleukin-1 beta Convertase, IL-1BC, Interleukin-1
beta-Converting Enzyme, IL-1 beta-converting Enzyme, ICE, p45, Caspase-1 Subunit p20,
Caspase-1 Subunit p10, IL1BCE, IL1BC, CASP1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Caspase-1, also known as IL-1b-converting enzyme (ICE), is an aspartic protease that plays a key role in the inflammatory response and apoptosis. The active enzyme consists of a complex of two 20kD (aa120-297) and two 10kD (aa317-404) subunits which associate following cleavage of inactive precursors. Caspase-1 is required for proteolytic cleavage of the IL-1b precursor to form the active proinflammatory cytokine. Alternate splicing generates several additional Caspase-1 isoforms with deletions in the propeptide regions or also in the mature subunits. Within the large subunit, human Caspase-1 shares 61% aa sequence identity with mouse and rat Caspase-1.
Catalog #C2086-66Y
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 0.25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS, 0.02% sodium azide. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with PBS, 0.02% sodium chloride.
PurityPurified by immunoaffinity chromatography.
ImmunogenE.coli-derived recombinant human Caspase-1 (aa120-297).
SpecificityRecognizes human Caspase-1. Species sequence homology: mouse, rat (61%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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