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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -CASP1 (Caspase-1, CASP-1, Interleukin-1 beta Convertase, IL-1BC, Interleukin-1 beta-converting Enzyme, ICE, IL-1 beta-converting Enzyme, p45, IL1BC, IL1BCE)

Anti -CASP1 (Caspase-1, CASP-1, Interleukin-1 beta Convertase, IL-1BC, Interleukin-1
beta-converting Enzyme, ICE, IL-1 beta-converting Enzyme, p45, IL1BC, IL1BCE)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
Caspase-1/ICE (interleukin-1beta converting enzyme) is a member of the ICE family of cysteine proteases. Caspase-1 exists in many cells as an inactive 45kD proenzyme and is cleaved into 20kD and 10kD subunits which form the active caspase-1. Casapse-1/ICE cleaves the inactive form of interleukin-1beta (IL-1beta) to generate the active from of this pro-inflammatory cytokine. Like the other caspases, Caspase-1 plays a role in apoptosis. Overexpression of Caspase-1 in cells induced apoptosis, and Caspase-1-mediated apoptosis can be blocked by CrmA, a selective inhibitor of several caspases.
Catalog #C2086-68L
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 15aa from near the middle of human Caspase-1 conjugated to KLH.
SpecificityRecognizes human CASP1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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