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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 2 (Caspase-2 Apoptosis-related Cysteine Protease, CASP 2, CASP2, CASP-2, ICH 1, ICH1, ICH-1 Protease, ICH 1L, ICH-1L, ICH 1L/1S, ICH-1L/1S, Neural Precursor Cell Expressed Developmentally Down-regulated 2, NEDD 2, NEDD2, NEDD-2 Apoptosis Regulator

Anti -Caspase 2 (Caspase-2 Apoptosis-related Cysteine Protease, CASP 2, CASP2, CASP-2, ICH
1, ICH1, ICH-1 Protease, ICH 1L, ICH-1L, ICH 1L/1S, ICH-1L/1S, Neural Precursor Cell
Expressed Developmentally Down-regulated 2, NEDD 2, NEDD2, NEDD-2 Apoptosis Regulator

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis.
In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle.
Catalog #C2086-71W
ApplicationsSuitable for use in Immunohistochemistry (paraffin) and Western Blot. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 10ug/ml
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 6aa near the amino-terminus of human Caspase-2.
SpecificityRecognizes human Caspase-2. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesApoptosis-related Cysteine Peptidase


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