Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 2 (Caspase-2 Apoptosis-related Cysteine Protease, CASP 2, CASP2, CASP-2, ICH 1, ICH1, ICH-1 Protease, ICH 1L, ICH-1L, ICH 1L/1S, ICH-1L/1S, Neural Precursor Cell Expressed Developmentally Down-regulated 2, NEDD 2, NEDD2, NEDD-2 Apoptosis Regulator

Anti -Caspase 2 (Caspase-2 Apoptosis-related Cysteine Protease, CASP 2, CASP2, CASP-2, ICH
1, ICH1, ICH-1 Protease, ICH 1L, ICH-1L, ICH 1L/1S, ICH-1L/1S, Neural Precursor Cell
Expressed Developmentally Down-regulated 2, NEDD 2, NEDD2, NEDD-2 Apoptosis Regulator

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
Recombinant mouse anti-human caspase-2 is a 53kD member of the cysteine-aspartic acid protease (caspase) family. Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis. In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle. Removal of Sodium Azide is recommended prior to use in functional assays.
Catalog #C2086-71Y
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No10B465
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant human caspase-2 (aa32-169) purified from E.coli.
SpecificityRecognizes recombinant human caspase-2 at ~53kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesApoptosis-related Cysteine Peptidase


External Links