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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 2 (ICH-1, Nedd2, Caspase-2, CASP-2, Neural Precursor Cell Expressed Developmentally Down-regulated Protein 2, NEDD-2, Protease ICH-1, CASP2)

Anti -Caspase 2 (ICH-1, Nedd2, Caspase-2, CASP-2, Neural Precursor Cell Expressed
Developmentally Down-regulated Protein 2, NEDD-2, Protease ICH-1, CASP2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Caspase 2 is a member of ICH1 group of cystein proteases involved in the activation of apoptotic pathway. It is synthesized as a procaspase2 containing a prodomain, a large subunit and a small subunit. RAIDD, another molecule involved in triggering the apoptotic pathway recruits caspase 2 through its CARD domain. Procaspase 2 iscleaved by active caspases 1 and 3 and granzyme into a heterodimer of large and small subunit, both of which are required for the activity. Caspase 2 exists in two isoforms, long and short created through the alternate splicing of the mRNA. The long form activates apoptosis while, the short form is inhibitory.
Catalog #C2086-72Q
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Immunohistochemistry (paraffin): 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with sterile dH2O.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide mapping at the C-terminal of human Caspase 2, identical to the related rat sequence.
SpecificityRecognizes human Caspase 2. Species Cross-Reactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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