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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 2, NT (casp2)

Anti -Caspase 2, NT (casp2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase- 1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1b and IL-18. Although phylogenetically similar to this subfamily, caspase-2 is thought to be involved in stress-induced apoptosis. Caspase-2 has two major isoforms; over-expression on the long form results in apoptosis while that of the short form suppresses cell death. Zebrafish has been used as a model for the research of caspase-2 functions.
Catalog #C2086-79A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Control Peptide C2086-79E
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceZebrafish
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the N-terminal region of zebrafish Caspase-2.
SpecificityRecognizes zebrafish Caspase-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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