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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -CASP4, NT (Caspase-4, CASP-4, ICH-2 Protease, TX Protease, ICE(rel)-II, Caspase-4 Subunit 1, Caspase-4 Subunit 2, ICH2)

Anti -CASP4, NT (Caspase-4, CASP-4, ICH-2 Protease, TX Protease, ICE(rel)-II, Caspase-4
Subunit 1, Caspase-4 Subunit 2, ICH2)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
CASP4 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, it induces cell apoptosis.
Catalog #C2087-24A9
ApplicationsSuitable for use in Western Blo and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 16aa from the N-terminus of human Caspase-4 conjugated to KLH.
SpecificityRecognizes human CASP4. Species sequence homology: Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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