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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 7, CT (Caspase-7, CASP 7, CASP7, CASP-7, Apoptosis-related Cysteine Peptidase, Apoptosis Related Cysteine Protease, Apoptotic Protease MCH3, CMH 1, CMH-1, ICE-like Apoptotic Protease 3, ICE LAP3, ICE-LAP3, MCH3)

Anti -Caspase 7, CT (Caspase-7, CASP 7, CASP7, CASP-7, Apoptosis-related Cysteine
Peptidase, Apoptosis Related Cysteine Protease, Apoptotic Protease MCH3, CMH 1, CMH-1,
ICE-like Apoptotic Protease 3, ICE LAP3, ICE-LAP3, MCH3)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B IH
Caspase-7, a 35kD cysteine protease, otherwise known as ICE-like Apoptotic Protease 3 (ICE-LAP3) is a member of the ICE/Ced-3 subfamily. Caspase-7 is an executioner caspase which undergoes proteolytic cleavage of its precursor to form active p12 and p20 subunits. Evidence that activation of Caspase-7 occurs during cell death induced by the cytokine death receptors
Fas/APO-1 and the receptor of tumor necrosis factor (TNFR-1), coupled with the fact that
granzyme-B activated Caspase-7 cleaves the nuclear enzyme poly (ADP-ribose) polymerase
(PARP), suggests an important role for Caspase-7 in both cytokine-mediated and Granzyme-B
mediated apoptosis pathways.
Catalog #C2087-29M
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Immunohistochemistry (Paraffin): 2ug/ml; Does not require protein digestion pre-treatment of paraffin embedded sections e.g. trypsin or pronase prior to staining. Does not require antigen retrieval using heat treatment prior to staining.
Optimal dilutions to be determined by the researcher.
IHC Positive ControlSkeletal Muscle Tissue
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified
Immunogen16 amino acid peptide from human Caspase-7 carboxy-terminus.
SpecificityRecognizes an epitope within the C-terminal region (CT) of human Caspase-7. Species Crossreactivity: Mouse, rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=3.4.22.60


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