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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 10, Pro-, p23/17 (Procaspase 10, FLICE2, Mch4)

Anti -Caspase 10, Pro-, p23/17 (Procaspase 10, FLICE2, Mch4)


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Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP IH IC FC
Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-10 (MCH4, FLICE2) is one of the initiator caspases (1,2), and is localized to various tissues. Pro-caspase-10 has two death effector domains (DEDs) that bind FADD and recruits both TNFR1 and CD95 to form complexes with these receptors and induce apoptosis (1,2). This death domain complex cleaves pro-caspase-10 into a large active fragment and a small fragment. Cleaved caspase-10 leads to the processing of caspase-3 and caspase-7, initiating a caspase cascade and subsequent apoptosis (3,4).
Catalog #C2087-72B
ApplicationsSuitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 1:50
Western Blotting: 1:1,000
Immunohistochemistry: 1:50-1:100
Immunocytochemistry: 1:100
Immunoprecipitation: 1:10
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No6k84
FormSupplied as a liquid
ImmunogenA synthetic peptide corresponding to N-terminal residues of human Caspase-10 subunit p23/17
SpecificityRecognizes human Caspase-10 subunit p23/17
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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