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You are here:Home » Antibodies » Antibodies-Apoptosis, Caspase » Anti -Caspase 10 (FLICE2, Mch4)

Anti -Caspase 10 (FLICE2, Mch4)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Caspases are death effector domain-containing cysteine aspartases presumed to be at or near the apex of apoptotic signaling pathways. All known isoforms of caspase-10 are abundantly expressed in fetal lung, kidney, and skeletal muscle but are very poorly expressed or absent in these tissues in the adult, implying a possible role for the caspase-10 family in fetal development.
Catalog #C2088-44
Caspase-10 belongs to DED (death effector domain) containing caspases and functions as an initiator caspase in Fas/TNF induced apoptosis (1). Four isoforms of caspase-10 have been identified caspase-10a (Mch4), caspase-10b (FLICE2), caspase-10c
and caspase-10d. They have the same prodomain but different mature large and small subdomains (2–4). Upon death ligand–receptor binding, caspase-10 is coupled to the multimeric Fas/TNF receptor complex via DED/FADD adaptor interaction (1–4). This complex processes procaspase-10 into a large active subunit and a small subunit. Cleaved caspase-10 further processes other caspase members, including caspase-3 and caspase-
7, to initiate a caspase cascade, leading to programmed cell death (3–6).
ApplicationsSuitable for use in Western Blot . Other applications not tested.
Recommended DilutionWestern Blot 1:250-1:500
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide before the addition of 40% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenN-terminus of all isoforms of human Caspase-10
SpecificityReacts with the N terminus of all isoforms of human Caspase-10.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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