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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 10, aa505-521, CT (FLICE2, Mch4)

Anti -Caspase 10, aa505-521, CT (FLICE2, Mch4)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch41,2 and renamed as caspase-10. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis1.
Catalog #C2088-50
Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP. Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death (3). Caspase-10 is expressed in many tissues and cell lines (1,2).
This polyclonal antibody can be used for detection of caspase-10 by Western blot at 1500 to 1:1000 dilution. HeLa whole cell lysate can be used as positive control and a 59kD band should be detected. This antibody only recognizes FLICE2 form of caspase-10. It is human and mouse reactive.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified IgG
ImmunogenPeptide corresponding to amino acids 505 to 521 of human FLICE21.
SpecificityA 59kD band should be detected. Only recognizes FLICE2 form of caspase-10. It is human and mouse reactive.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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