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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 11 (Casp4, Caspase 4, Aoptosis-related cysteine peptidase, Casp11, ASP-4, Caspase-4, Caspl, Ich3, ich-3, Protease ICH-3)

Anti -Caspase 11 (Casp4, Caspase 4, Aoptosis-related cysteine peptidase, Casp11, ASP-4,
Caspase-4, Caspl, Ich3, ich-3, Protease ICH-3)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified B FC
Caspase-11, (also known as CASP-11, ICH-3, ICE-B) promotes IL-b processing by procaspase-1 (ICE) and therefore may also have a role in inflammatory response as evident by a 30 fold increase in CASP-11 activity by LPS. The mouse and rat CASP-11 (373aa) are most homologous to human CASP-4 (377aa) protein (ICErel-II, TX, ICH-2) and could possibly be the ortholog of human CASP-4. The pro-or zymogen form of CASP-11 is activated by Granzyme-B or cathepsin-B and the processed enzyme consists of two large p20 (20kD) and two small ~p10 (10kDa subunits. CASP-11 is highly expressed in lung and spleen, weaker in heart and very little in liver, kidney, testis and skeletal muscle but has not been detected in the brain.
Catalog #C2088-56D
ApplicationsSuitable for use in Flow Cytometry, Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: detects two bands of ~38kD and ~43kD.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D225
HostRat
SourceMouse
Concentration1mg/ml
FormSupplied as a liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenP20 fragment of mouse caspase-11.
SpecificityRecognizes mouse caspase-11 (epitope in the p20 fragment). Species Crossreactivity: Rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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