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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 11 (Casp4, Caspase 4, Aoptosis-related cysteine peptidase, Casp11, ASP-4, Caspase-4, Caspl, Ich3, ich-3, Protease ICH-3)

Anti -Caspase 11 (Casp4, Caspase 4, Aoptosis-related cysteine peptidase, Casp11, ASP-4,
Caspase-4, Caspl, Ich3, ich-3, Protease ICH-3)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Caspase-11, (also known as CASP-11, ICH-3, ICE-B) promotes IL-b processing by procaspase-1 (ICE) and therefore may also have a role in inflammatory response as evident by a 30 fold increase in CASP-11 activity by LPS. The mouse and rat CASP-11 (373aa) are most homologous to human CASP-4 (377aa) protein (ICErel-II, TX, ICH-2) and could possibly be the ortholog of human CASP-4. The pro-or zymogen form of CASP-11 is activated by Granzyme-B or cathepsin-B and the processed enzyme consists of two large p20 (20kD) and two small ~p10 (10kDa subunits. CASP-11 is highly expressed in lung and spleen, weaker in heart and very little in liver, kidney, testis and skeletal muscle but has not been detected in the brain.
Catalog #C2088-56E
ApplicationsSuitable for use in Western Blot and ELISA. Other applications not tested.
Recommended DilutionsWestern Blot: 1-10ug/ml (ECL)
ELISA: 0.5-1ug/ml. Control peptide (Cat #C2088-56F) can be used to coat ELISA plates at 1ug/ml.
Optimal dilution determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, 0.1% BSA. Reconstitute with 100ul sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa286-298, near the C-terminus of mouse caspase 11.
Species Sequence HomologyRat, 84%
SpecificityRecognizes mouse Caspase 11.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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