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You are here:Home » Antibodies » Abs to Apoptosis, Caspase » Anti -Caspase 11 (Casp4, Caspase 4, Aoptosis-related cysteine peptidase, Casp11, ASP-4, Caspase-4, Caspl, Ich3, ich-3, Protease ICH-3)

Anti -Caspase 11 (Casp4, Caspase 4, Aoptosis-related cysteine peptidase, Casp11, ASP-4,
Caspase-4, Caspl, Ich3, ich-3, Protease ICH-3)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified B IP IH
Caspase-11, (also known as CASP-11, ICH-3, ICE-B) promotes IL-b processing by procaspase-1 (ICE) and therefore may also have a role in inflammatory response as evident by a 30 fold increase in CASP-11 activity by LPS. The mouse and rat CASP-11 (373aa) are most homologous to human CASP-4 (377aa) protein (ICErel-II, TX, ICH-2) and could possibly be the ortholog of human CASP-4. The pro-or zymogen form of CASP-11 is activated by Granzyme-B or cathepsin-B and the processed enzyme consists of two large p20 (20kD) and two small ~p10 (10kDa subunits. CASP-11 is highly expressed in lung and spleen, weaker in heart and very little in liver, kidney, testis and skeletal muscle but has not been detected in the brain.
Catalog #C2088-56H
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry (Fr). Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No8J508
HostRat
SourceMouse
Concentration~1mg/ml
Form15mM Sodium Azide; 1% BSA, 0.01M PBS. pH 7.4
PurityPurified by Protein A affinity chromatography.
ImmunogenA recombinant p30 subunit of Mouse Caspase 11.
SpecificitySpecies Crossreactivity: Crossreacts with Mouse.Expected to crossreact with Rat due to sequence homology.Not yet tested in other species.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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