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You are here:Home » Antibodies » Antibodies-Apoptosis, Caspase » Anti -Caspase 11 (Caspase-4, CASP-4, Caspase-11, CASP-11, Protease ICH-3, Casp4, Casp11, Caspl, Ich3)

Anti -Caspase 11 (Caspase-4, CASP-4, Caspase-11, CASP-11, Protease ICH-3, Casp4, Casp11,
Caspl, Ich3)


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Clone Host Grade Applications
Monoclonal Rat Affinity Purified B
Murine caspase-11 is an upstream protease of caspase-1 and interacts with the proform of caspase-1 which in turn activates IL-1 beta. Caspase-11 is not constitutively expressed in most cell types. Its expression can be upregulated by LPS, IFN-gamma, and other pro-inflammatory stimuli. NF-kB and STAT1 were reported to be involved in the activation. Caspase-11 knock -out mice were resistant to endotoxin shock and do not produce IL-1 after stimulation with LPS. Their production of IFN-gamma was also deficient.
Catalog #C2088-56J
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
FormSupplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenHis tagged bacterial fusion protein of p 30 of caspase 11
SpecificityRecognizes mouse Caspase-11.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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